Chiral mobile phase additives for improved liquid-chromatography separations
US5338454A · kind A · utility
7Cited by
1References
16Claims
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Assignee
Inventor
Key dates
| Filing date | Aug 27, 1992 |
| Grant date | Aug 16, 1994 |
| Priority date | — |
| Expiry date | Aug 27, 2012 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2220/58
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Chromatographic separations and resolutions of racemic mixtures and diastereoisomers are enhanced by simultaneously employing an enantiomeric, chiral stationary phase (CSP) and an enantiomeric, chiral mobile phase additive (CMPA) bearing a stereoisomeric relationship to the CSP but having the opposite chirality are enhanced relative to the use of either a CSP or a CMPA alone. Specific CMPA compositions having the structural formulas ##STR1## are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.