Method for determining analyte concentration by cross-reactivity profiling
US5338659A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 2, 1991 |
| Grant date | Aug 16, 1994 |
| Priority date | — |
| Expiry date | Apr 2, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/901
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The precision of identification of analyte composition in a sample, where the possible analytes cross-react with specific binding reagents, is enhanced by applying pattern recognition techniques. Samples to be tested are reacted with a panel of specific binding reagents reactive with the set of analytes to be tested to obtain a pattern of reactivity with respect to each analyte at a given concentration. This results in a databank of "CRIM profiles" for known concentrations of each analyte. This databank is stored in a computationally accessible form, which then can be matched against CRIM patterns obtained by testing unknown samples. In one embodiment, each CRIM pattern obtained is plotted as a single point in n-dimensional space, wherein n represents the number of specific binding reagents in the panel. Because a different CRIM profile as a function of concentration is obtained with each analyte, a pattern of points in n-dimensional space can be constructed for various concentrations of each individual member. Mathematical techniques can be used to project the pattern from n-dimensional space to reduce dimensionality. The location of a point yielded by a sample of unknown concentr…
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