Microbiological process for the production of malonyl-7-amino-cephalosporanic acid derivatives using Sphingomonas sp. DSM 7007
US5338667A · kind A · utility
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Key dates
| Filing date | Apr 27, 1993 |
| Grant date | Aug 16, 1994 |
| Priority date | — |
| Expiry date | Apr 27, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/822
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed is a microbiological process which utilizes a biologically pure culture of Sphingomonas sp. DSM 7007 in order to produce a malonyl-7-aminocephalosporanic acid derivative product. Furthermore the process uses cephalosporin C derivative as a substrate for the conversion of the cephalosporin C into the product. The process takes place by one time or continuous addition of substrate so that the concentration of cephalosporin C does not exceed 20 percent by weight. Furthermore, the process is performed at a temperature range of 0-60 degrees celsius and a pH range of 5 to 9.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.