Bisphosphonates, processes for preparation and pharmaceutical compositions containing the same

US5338731A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Eli Breuer · Jerusalem, IL
• Gershon Golomb · Beer Sheva, IL

Key dates

• Filing date: Mar 8, 1993
• Grant date: Aug 16, 1994
• Expiry date: Mar 8, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/3886
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Bisphosphonate compounds are of the Formula (I): ##STR1## wherein Y is .dbd.O or .dbd.N--OH and n is from 3 to 24, and further wherein when Y is .dbd.O, (i) R.sub.1 is hydrogen and R.sub.2 is sodium, or (ii) R.sub.1 is sodium and R.sub.2 is methyl, and when Y is .dbd.N--OH, R.sub.1 is sodium and R.sub.2 is methyl.