Topical composition and method containing deoxy and halo derivatives of lysophosphatidic acids for regulating skin wrinkles

US5340568A · kind A · utility

Assignee

• The Procter & Gamble Company · US

Inventors

• Gary A. Piazza · Doylestown, US
• Adam W. Mazur · Cincinnati, US
• Gerald B. Kasting · Wyoming, US

Key dates

• Filing date: Jul 1, 1992
• Grant date: Aug 23, 1994
• Expiry date: Jul 1, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q17/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject invention relates to compositions and methods for regulating wrinkles in mammalian skin by topical application of a 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound having the structure: ##STR1## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms; each --X-- is independently --0-- or --S--; --Y-- is --0-- or --CH.sub.2 --; and Z is --H or halo.