Method and compositions for treating tumors having high tyrosinase activity
US5340803A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 5, 1993 |
| Grant date | Aug 23, 1994 |
| Priority date | — |
| Expiry date | May 5, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/549
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tumor cells which have .beta.-glucuronidase and tyrosinase activity are selectively treated by administration of a conjugate of a cytotoxic compound which is a substrate for tyrosinase and glucuronic acid or a pharmaceutically acceptable salt or ester thereof particularly the methyl-triacetylated form of glucuronic acid. Among the cytotoxic phenolic compounds which are substrates for tyrosinase which can be used are 4-hydroxyanisole, butylated hydroxyanisole, L-3,4-dihydroxy-phenylalanine, dopamine (3,4-dihydroxyphenethylamine), terbutylcatechol, hydroquinone, resorcinol, 6-hydroxydopa (3,4,6-trihydeoxyphenylalanine) and methyl gallate. The efficacy of the treatment is enhanced by also administering a compound that inhibits the action of glutathione reductase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.