Pharmaceutical compositions comprising cyclosporins

US5342625A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Birgit Hauer · Lahr (Eifel), DE
• Armin Meinzer · Glückstadt, DE
• Ulrich Posanski · Glückstadt, DE
• Friedrich Richter · Schönbühl, CH

Key dates

• Filing date: Dec 15, 1992
• Grant date: Aug 30, 1994
• Expiry date: Dec 15, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/4858
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or [Nva].sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.