Preparation of water soluble camptothecin derivatives
US5342947A · kind A · utility
45Cited by
12References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 9, 1992 |
| Grant date | Aug 30, 1994 |
| Priority date | — |
| Expiry date | Oct 9, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to the synthesis of water soluble, camptothecin derivatives of formula (I), ##STR1## wherein: n represents the integer 1 or 2; PA0 R.sup.1 represents independently, hydrogen, lower alkyl, (C.sub.3-7)cycloalkyl, (C.sub.3-7)cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, lower alkoxy lower alkyl; and PA0 R.sup.2 represents hydrogen and the pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.