Azomethines agonist compounds of the histamine H.sub.3 receptor for therapeutic use, pharmaceutical compositions acting as agonists of the said receptor and preparation process

US5342960A · kind A · utility

Assignees

• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• BIOPROJET · FR

Inventors

• Monique Garbarg · Paris, FR
• Jean-Michel Arrang · Gif-sur-Yvette, FR
• Walter Schunack · Berlin, DE
• Ralph Lipp · Berlin, DE
• Holger Stark · Bad Homburg vor der Höhe, DE
• Jeanne-Marie Lecomte · Paris, FR
• Jean-Charles Schwartz · Paris, FR

Key dates

• Filing date: Feb 6, 1992
• Grant date: Aug 30, 1994
• Expiry date: Feb 6, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Agonist compounds of the histamine H.sub.3 receptor for therapeutic use, pharmaceutical compositions acting as agonists of the said receptor and preparation process are disclosed. The compounds are derived from an amine R-NH.sub.2 having a high affinity for the histamine H.sub.3 receptor and to the primary amine function of which a group which gives rise to a bond that is capable of being slowly hydrolyzed in a neutral medium is attached. The pharmaceutical compositions contain these compounds and a pharmaceutically acceptable vehicle or excipient. These compounds are used for producing a medicinal product which inhibits the synthesis and the release of histamine, in particular, possessing sedative, sleep-regulating, anticonvulsant, antidepressant, anti-allergic, anti-inflammatory, antisecretory or anti-ulcerous effects.