Method for manufacturing freeze dried dosages in a multilaminate blister pack
US5343672A · kind A · utility
Inventors
Key dates
| Filing date | Dec 1, 1992 |
| Grant date | Sep 6, 1994 |
| Priority date | — |
| Expiry date | Dec 1, 2012 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB32B2439/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An improved method for manufacturing freeze dried pharmaceutical tablets in blister packs is disclosed. Liquid dosages are introduced into a multilayer laminated blister sheet having an impermeable intermediate layer that is positioned between first and second outer layers, each of which has substantially the same coefficient of thermal expansion. The properties of the outer layers of the blister sheet are such that there are no inter-layer stresses that will cause curvature of the blister sheet when it is subjected to temperature changes during the freezing and freeze drying steps. Following the introduction of the dosages into the depressions of the blister sheet, the dosages are frozen and freeze dried. A lidding sheet is then attached to the blister sheet to seal the solid dosages into the blister pack.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.