Human uterine tissue plasminogen activator produced by recombinant DNA

US5344773A · kind A · utility

Assignee

• Genzyme Corporation · US

Inventors

• Cha-Mer Wei · Seattle, US
• Nancy Hsiung · Wellesley, US
• Vermuri B. Reddy · Lowell, US
• Jeffrey F. Lemontt · Newton, US
• William Dackowski · Hopkinton, US
• Richard M. Douglas · Upton, US
• Edward S. Cole · Bolton, US
• Richard D. Purcell, Jr. · Newton, US
• David Tai-Yui Lau · Marlboro, US

Key dates

• Filing date: Oct 1, 1985
• Grant date: Sep 6, 1994
• Expiry date: Oct 1, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/85
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A replicable expression vector capable, in a transformed host mammallian cell, of expressing a DNA sequence encoding active human TPA which, when expressed in the host cell, yields active TPA which lacks one or more of the TPA-bound N-linked carbohydrate moieties of naturally occurring human TPA.