Piperidine and pyrrolidine derivatives

US5344835A · kind A · utility

Assignee

• PFIZER INC. · US

Inventors

• David Alker · Birchington, GB
• Peter E. Cross · Canterbury, GB

Key dates

• Filing date: Jul 2, 1992
• Grant date: Sep 6, 1994
• Expiry date: Jul 2, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

According to the invention there is provided a compound of formula (I): R.sup.1 --O(CH.sub.2).sub.m A(CH.sub.2).sub.n XR or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is a group of formula (a or b) where Z is --(CH.sub.2).sub.2-, --CH.dbd.CH--, --CH.sub.2 --S-- or --CH.sub.2 --O--; R is a group of formula (c, d or Het) and A is a group of formula (e, f or g) in which the N atom is attached to the group (CH.sub.2)n; m is 1 or 2; n is an integer of from 1 to 4; p is 1, 2 or 3; R.sup.2 and R.sup.3 are each independently hydrogen, C.sub.1 -C.sub.4 alkyl, hydroxy-(C.sub.1 -C.sub.4 alkyl), hydroxy, C.sub.1 -C.sub.4 alkoxy, halo, trifluoromethyl, nitro, cyano, sulphamoyl, --CO(C.sub.1 -C.sub.4 alkyl), --OCO(C.sub.1 -C.sub.4 alkyl), carboxy, --CO.sub.2 (C.sub.1 -C.sub.4 alkyl), --CH.sub.2).sub.q CONR.sup.4 R.sup.5, -- (CH.sub.2).sub.q OCONR.sup.4 R.sup.5, --CH.sub.2).sub.q NR.sup.6 R.sup.7 or --NHSO.sub.2 NH.sub.2 in which R.sup.4 and R.sup.5 are each independently H or C.sub.1 -C.sub.4 alkyl, q is 0, 1 or 2, and either R.sup.6 and R.sup.7 are each independently H or C.sub.1 -C.sub.4 alkyl or R.sup.6 is hydrogen and R.sup.7 is --SO.sub.2 (C.sub.1 -C.sub.4 alkyl), --CO(C.su…