Nail lacquer for the treatment of onychomycosis

US5346692A · kind A · utility

Assignee

• Roehm Pharma GmbH · DE

Inventors

• Wolfgang Wohlrab · Bodenwerder, DE
• Katrin Wellner · Bodenwerder, DE

Key dates

• Filing date: Apr 8, 1993
• Grant date: Sep 13, 1994
• Expiry date: Apr 8, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q3/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a nail lacquer for treating onychomycosis, comprised of a film-forming agent, an antimycotically active substance, and urea, wherewith the antimycotically active substance and the urea are liberated from the lacquer when the lacquer is applied. A preferred formulation comprises cellulose derivative(s) as film former(s), clotrimazole as the antimycotic (present in the amount of 5-30 wt. % based on the weight of the non-volatile components), urea (present in the amount of 15-60 wt. % based on the weight of the non-volatile components), and dibutyl phthalate as a plasticizer, in a solvent mixture comprised of acetone and ethanol.