Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization

US5346702A · kind A · utility

Assignee

• Sterling Winthrop Inc. · US

Inventors

• George C. Na · Fort Washington, US
• Natarajan Rajagopalan · Kothagudem, IN

Key dates

• Filing date: Dec 4, 1992
• Grant date: Sep 13, 1994
• Expiry date: Dec 4, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/915
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and a non-ionic cloud point modifier associated therewith, which cloud point modifier is present in an amount-sufficient to increase the cloud point of the surface modifier. A preferred surface modifier is a poloxamine such as Tetronic 908, and preferred non-ionic cloud point modifiers include polyethylene glycol, propylene glycol, ethanol, hydroxypropylcyclodextrin and/or glycerol. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and a non-ionic cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.