Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase
US5346828A · kind A · utility
37Cited by
6References
17Claims
0Family size
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Key dates
| Filing date | Mar 2, 1992 |
| Grant date | Sep 13, 1994 |
| Priority date | — |
| Expiry date | Mar 2, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/829
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Mixtures of enantiomeric D,L-threo 2-amino-3-hydroxy-3-phenylpropionic acids can be stereoisomerically enriched by contacting the mixture with a D-threonine aldolase. In a typical embodiment, D- and L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid is treated with D-threonine aldolase to produce L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid with a high ee. The benzaldehyde and amino acid formed from the D-threo isomer can be recycled.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.