Preparation of copper 2-alkoxyisobutylisonitrile complexes and .sup.99m Tc labelling of 2-alkoxyisobutylisonitrile
US5346995A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 13, 1993 |
| Grant date | Sep 13, 1994 |
| Priority date | — |
| Expiry date | Jan 13, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F13/005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new method for synthesizing 2-alkoxyisobutylisonitrile is provided in which isobutylene is used as the starting material. The haloalkoxylation of isobutylene in alcohol medium gives 2-alkoxyisobutylhalide which is then converted to 2-alkoxyisobutylamine. In the basic condition, the reaction of 2-alkoxyisobutylamine with chloroform produces 2-alkoxyisobutylisonitrile. The synthesis process contains three steps by which a higher yield is achieved. 2-Alkoxyisobutylisonitrile is labelled with technetium-99m by exchange labelling of stable tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex. Tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex can be prepared by the exchange of acetonitrile molecules in tetrakis(acetonitrile)copper(I) complex with isonitrile ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.