Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
US5346996A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 14, 1992 |
| Grant date | Sep 13, 1994 |
| Priority date | — |
| Expiry date | Sep 14, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/80
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to rare earth cryptates consisting of at least one rare earth salt complexed by a macropolycyclic compound corresponding to one of formulae I or II below, in which: PA1 the ring ##STR1## is the N.sub.2 O.sub.4 macrocycle, the N.sub.2 O.sub.3 macrocycle or the bis-bipyridine macrocycle; PA1 Y is a spacer arm or group which consists of a divalent organic radical selected from linear or branched C.sub.1 to C.sub.20 alkylene groups optionally containing one or more double bonds and/or optionally being interrupted by one or more heteroatoms such as oxygen, nitrogen, sulfur or phosphorus, or from C.sub.5 to C.sub.8 cycloalkylene groups or C.sub.6 to C.sub.14 arylene groups, the said alkylene or arylene groups optionally being substituted by alkyl, aryl or sulfonate groups; PA1 Z is a functional group capable of bonding covalently with a biological substance; PA1 R is a methyl group or represents the group --Y--Z; and PA1 R' is hydrogen or a group --COOR", in which R" is a C.sub.1 to C.sub.10 alkyl group and preferably represents the methyl, ethyl or tert.-butyl group, or alternatively R' is a group --CO--NH--Y--Z. ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.