Method of preparing 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5347007A · kind A · utility
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2References
1Claims
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Key dates
| Filing date | Oct 4, 1993 |
| Grant date | Sep 13, 1994 |
| Priority date | — |
| Expiry date | Oct 4, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is provided for preparing 7-oxabicycloheptyl substituted heterocyclic aide prostaglandin analogs which are thromboxane A.sub.2 (TXA.sub.2) receptor antagonists or combined thromboxane A.sub.2 receptor antagonists/thromboxane synthetase inhibitors useful, for example, in the treatment of thrombotic and/or vasospastic disease, wherein a vinyl bromide of the formula, for example, ##STR1## wherein m, n, R.sup.1 and R.sup.2 are as defined herein is treated with a cyclizing agent to forth the corresponding oxazole.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.