Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents
US5347029A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 16, 1993 |
| Grant date | Sep 13, 1994 |
| Priority date | — |
| Expiry date | Dec 16, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6506
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided are novel dialkyl (dialkoxyphosphinyl)methyl phosphates of formula ##STR1## which am useful as anti-inflammatory and anti-arthritic agents. The compounds are synthesized from the reaction of tetraethyl oxiranylidenebisphosphonate and unsubstituted or alkyl-amines. Representative compounds include 2-(benzylamino)-1-(diethoxyphosphinyl)ethyl phosphonic acid diethyl ester, 1-(diethoxyphosphinyl)-2-[2'-(1', 2', 3', 4'-tetrahydro)napthylamino]ethyl phosphonic acid diethyl ester, 2-(3-fluorobenzylamino)-1-(diethoxyphosphinyl)ethyl phosphonic acid diethyl ester, and 5,5 -dimethyl-2-[2-(3-fluorobenzyl)amino-1-[(5,5-dimethyl-1,3,2-dioxaphosphori nan-2-yl)oxy]ethyl]-1,3,2-dioxaphosphorinane P,2-dioxide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.