IgG3 antibodies with shortened hinge region and a complement activation test
US5348876A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 12, 1992 |
| Grant date | Sep 20, 1994 |
| Priority date | — |
| Expiry date | Mar 12, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/44
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides modified IgG3 containing human constant regions which has a shorter total-hinge region compared with normal human IgG3. Also described is a method for assaying an antibody against a specific antigen or hapten for its effectiveness in complement activation in an animal species, wherein the antibody is contacted with the immobilized antigen or hapten to form an immobilized antibody/antigen or hapten complex which is then contacted with complement from the relevant animal species, followed by assay of components of the complement complex thereby formed; whereby the extent and nature of complement activation by the antibody in the sample may be determined.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.