Stabilizers for fibroblast growth factors
US5348941A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 1, 1992 |
| Grant date | Sep 20, 1994 |
| Priority date | — |
| Expiry date | Apr 1, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Medicinal compositions containing fibroblast growth factor are stabilized against loss of biological activity by including in said composition a stabilizing amount of phytic add, phosvitin, phosphate buffer, (NH.sub.4).sub.6 P.sub.4 O.sub.13, Na.sub.5 P.sub.3 O.sub.10, Na.sub.4 P.sub.2 O.sub.7 and Na.sub.3 P.sub.3 O.sub.9, adenosine tetra, tri, di and mono phosphate and related diadenosine compounds plus other single and multi-phosphorylated mono and di-nucleotides, poly-aspartic acid, poly-adenylic-guanylic add and related compounds, double stranded deoxyribonucleic add, single stranded deoxyfibonucleic acid and poly-glutamic acid. Medicinal compositions for topical use are combined with a viscous excipient such as a water soluble polysaccharide with said combination with a second stabilizier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.