Substituted cyclopropylamino-1,3,5-triazines

US5348956A · kind A · utility

Assignee

• UCB S.A. · BE

Inventors

• Berend Jan Van Keulen · Tubize, BE
• Solo Goldstein · Suresnes, FR
• Eric Cossement · Brussels, BE
• Jean Gobert · Maisons-Alfort, FR
• Ernst Wulfert · Brussels, BE

Key dates

• Filing date: Aug 9, 1993
• Grant date: Sep 20, 1994
• Expiry date: Aug 9, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New substituted cyclopropylamino-1,3,5-triazines having the formula ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.3 -alkyl, C.sub.3 -C.sub.5 -cycloalkyl or C.sub.1 -C.sub.3 -alkyl-C.sub.3 -C.sub.5 -cycloalkyl PA0 R.sub.2 is bis(2-hydroxyethyl)amino, 3-hydroxy-1-azetidinyl, 3-methoxy-1-azetidinyl, 3-oxo-1-azetidinyl, morpholino, 4-hydroxypiperidino, thiomorpholino, thiomorpholino S-oxide, thiomorpholino S,S-dioxide, 3-thiazolidinyl, 3-thiazolidinyl S-oxide, 3-thiazolidinyl S,S-dioxide or 8-oxa-3-azabicyclo[3,2,1]oct-3-yl. Processes for the preparation thereof and pharmaceutical composition containing them are also given. The compounds are useful for the treatment of inflammation and asthma.