Angiotensin converting enzyme inhibitors

US5348978A · kind A · utility

Assignee

• Fisons plc · GB

Inventors

• Andrew Baxter · Loughborough, GB
• Premji Meghani · West Bromwich, GB

Key dates

• Filing date: Dec 10, 1992
• Grant date: Sep 20, 1994
• Expiry date: Dec 10, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Angiotensin converting enzyme inhibitors have the formula Z(CH.sub.2).sub.n CHR.sub.1 COOCHR.sub.2 COOH PA1 in which Z is --SR.sub.3, --COCHR.sub.4 NHCOR.sub.5, ##STR1## or --NHCHR.sub.7 COOH, R.sub.4, R.sub.5, R.sub.6, and R.sub.7, which may be the same or different, are each phenyl or alkylphenyl C.sub.7-12, PA1 R.sub.4 is hydrogen, alkyl C.sub.1-6, NHR.sub.8 or (CH.sub.2).sub.p R.sub.9, PA1 R.sub.2 is (CH.sub.2).sub.m XR.sub.10, alkyl C.sub.1-6 optionally substituted by a saturated 5- or 6-membered carbocyclic or heterocyclic ring, alkylhalo C.sub.1-6, alkylcyano C.sub.1-6, or alkyl phenyl C.sub.7-12, the phenyl being optionally substituted by NO.sub.2 or NH.sub.2, PA1 X is O, S(O).sub.q, C.dbd.O or NR.sub.11, and PA1 R.sub.10 is alkyl C.sub.1-6, alkylhalo C.sub.1-6, alkoxy C.sub.1-6, alkoxy C.sub.1-6 substituted by halogen, alkanoyl C.sub.1-6, S(O).sub.r R.sub.12, NR.sub.13 R.sub.14, phenyl, alkylphenyl C.sub.7-12, naphthalenyl or a 5-membered unsaturated heterocyclic ring, PA1 n is an integer from 0 to 6, PA1 m and p, which may be the same or different, are each an integer from 1 to 6, PA1 R.sub.9 is hydrogen, SR.sub.15 or phenyl optionally substituted by OR.sub.16, PA1 R.sub.…