Method for the preparation of 4-phenyl-1,3-benzodiazepins and precursors thereof
US5349086A · kind A · utility
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Key dates
| Filing date | Nov 23, 1992 |
| Grant date | Sep 20, 1994 |
| Priority date | — |
| Expiry date | Nov 23, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D243/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of the formula ##STR1## is prepared by reacting an N-acylated-o-toluidine of the formula ##STR2## with n-alkyllithium to form a dilithio intermediate of the formula ##STR3## which can then be quenched with N-benzylidenemethylamine to form compound II. Hydrolysis of compound(II) yields the free base ##STR4## or its salt, which can be cyclized to form 4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine or its physiologically acceptable salts, which are useful as pharmacological agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.