Antibodies which bind to novel lymphokine related peptides

US5350687A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Karel Gerrit Odink · Rheinfelden, CH
• Roger Clerc · Binningen, CH
• Nico Cerletti · Bottmingen, CH
• Josef Bruggen
• Lajos Tarcsay · Weil am Rhein, DE
• Clemens Sorg · Munster, DE
• Walter Wiesendanger · Münchenstein, CH

Key dates

• Filing date: Nov 21, 1990
• Grant date: Sep 27, 1994
• Expiry date: Nov 21, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/702
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns polypeptides related to human macrophage migration inhibition factor, in particular the polypeptides called MRP-8 and MRP-14, processes for their preparation, mRNAs, DNAs and hybrid vectors coding for said polypeptides, hosts transformed with such a hybrid vector, monoclonal and polyclonal antibodies to said polypeptides , and diagnostic methods for inflammatory conditions and cystic fibrosis.