Bisphosphonic acid derivatives, as bone resorption inhibitors
US5350743A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 6, 1992 |
| Grant date | Sep 27, 1994 |
| Priority date | — |
| Expiry date | Feb 6, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65583
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A bisphosphonic acid derivative of the formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein A is ##STR2## each of R.sup.3 and R.sup.4, which may be the same or different, is (i) a hydrogen atom, (ii) a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.2-6 alkynyl group, a C.sub.1-6 alkyl-carbonyl group, a C.sub.2-6 alkenyl-carbonyl group, a C.sub.2-6 alkynyl-carbonyl group R.sup.5 and R.sup.6, which may be the same or different, is a hydrogen atom, a hydroxyl group, a halogen atom, a cyano group, a carbamoyl group, an aralkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted amino group, a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.2-6 alkynyl group; PA0 each of m and n is 0 or a positive integer, provided that (m+n) is from 2 to 5; and PA0 R is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.7-15 aralkyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.