Heterocyclic cycloalkanes
US5350754A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Mar 1, 1993 |
| Grant date | Sep 27, 1994 |
| Priority date | — |
| Expiry date | Mar 1, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D241/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns a heterocyclic cycloalkane of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; PA1 A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; PA1 X is oxy, thio, sulphinyl, sulphonyl or imino; PA1 Ar is phenylene which may optionally bear one or two substituents or PA1 Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; PA1 R.sup.1 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; PA1 and R.sup.2 and R.sup.3 together form a (3-6C)alkylene group which, together with the carbon atom to which R.sup.2 and R.sup.3 are attached, defines a ring having 4 to 7 ring atoms, and which ring may bear one or two substituents; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.