Use of a cytochrome oxidase inhibitor to increase the cough-suppressing activity of dextromorphan
US5350756A · kind A · utility
154Cited by
1References
6Claims
0Family size
Inventor
Key dates
| Filing date | May 28, 1992 |
| Grant date | Sep 27, 1994 |
| Priority date | — |
| Expiry date | May 28, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/485
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention discloses a method for increasing the effectiveness of dextromethorphan (DM) as an antitussive agent (i.e., as a cough suppressant). This method involves the concurrent administration of DM and a second agent which inhibits the oxidative activity of debrisoquin hydroxylase, a cytochrome P450 oxidase enzyme. Effective anti-oxidant compounds include quinidine, yohimbine, and fluoxetine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.