Localization and characterization of the Wilms' tumor gene
US5350840A · kind A · utility
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Key dates
| Filing date | Nov 20, 1991 |
| Grant date | Sep 27, 1994 |
| Priority date | — |
| Expiry date | Nov 20, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/30
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The Wilms' tumor gene associated with the 11p13 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in a limited number of cell types (e.g., predominantly kidney cells and ja subset of hematopoietic cells). The polypeptide encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.
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