Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same
US5352436A · kind A · utility
123Cited by
8References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1993 |
| Grant date | Oct 4, 1994 |
| Priority date | — |
| Expiry date | Nov 22, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/223
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is a mixture including a solvent, a first surfactant and a second, dispersible surfactant different from the first surfactant, the mixture having stabilized gas microbubbles formed therein by sonication. The gas microbubbles are useful in ultrasonic diagnostics. Preferably the first surfactant is substantially soluble in the solvent and the second surfactant is substantially insoluble in the solvent. The present invention also includes a process for preparing the stabilized gas microbubbles and a method for altering the contrast of an ultrasonic image using the microbubbles as a contrast agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.