Patent · US Expired

Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmaceutical compositions comprising them

US5352667A · kind A · utility

39Cited by
6References
16Claims
0Family size

Inventors

Key dates

Filing dateNov 19, 1992
Grant dateOct 4, 1994
Priority date—
Expiry dateNov 19, 2012

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K38/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Non-peptidic RXD analogues are provided that inhibit biological cellular and molecular interactions which are dependent on RXD recognition, wherein X is one of the amino acid residues G, E, Y, A or F. In particular, RGD surrogates are provided having no sequence of .alpha.-natural amino acids and comprising a guanidino and a carboxyl terminal groups spaced by a chain of 11 atoms, at least 5 of which are carbon atoms. The compounds inhibit cell adhesion and are useful for the treatment of several pathological disorders, e.g., thrombosis, autoimmune diseases, metastasis, allergy, host-graft reactions and inhibition of scar tissue formation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.