Heteroatoms-containing tricyclic compounds

US5352671A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Karl Baumann · Pickens, US
• Gerhart Emmer · Wien, AT

Key dates

• Filing date: May 9, 1991
• Grant date: Oct 4, 1994
• Expiry date: May 9, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/01
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns the compounds of formula I ##STR1## wherein the substituents have various significances. They are prepared by several processes including epimerizing replacement, treatment with cyanogen bromide or thiophosgene, treatment with an acid having a non-nucleophilic anion, treatment with dimethylsulfoxide and acetic anhydride, acylation, treatment with an oxalyl derivative and ammonia, methylation, oxidation, deprotection and protection. They possess interesting pharmacological activity as antiinflammatory, immunosuppressant, antiproliferative and chemotherapeutic drug resistance reversing agents.