Crosslinked antibodies and processes for their preparation
US5354554A · kind A · utility
36Cited by
6References
19Claims
0Family size
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Inventor
Key dates
| Filing date | Jan 22, 1992 |
| Grant date | Oct 11, 1994 |
| Priority date | — |
| Expiry date | Jan 22, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/866
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cross-linked labelled antibody conjugates are described which have at least one non-disulphide interchain bridge. The bridge may be the residue of a homo- or heterofunctional cross-linking reagent, and is located away from the antigen binding domains of the antibody. The antibody conjugates have an enhanced binding capacity and in vivo have good blood clearance and, in the presence of a tumour high tumour: blood and tumour: bone ratios. The conjugates are of use in the diagnosis and therapy of e.g. tumours and may be prepared by reaction of a cross-linking reagent with an antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.