Process for preparing micronized polypeptide drugs
US5354562A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 16, 1993 |
| Grant date | Oct 11, 1994 |
| Priority date | — |
| Expiry date | Feb 16, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/27
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Solid particle aerosol formulations of polypeptide drugs are made by lyophilizing solutions of the drugs which contain milling stabilizers that inhibit degradation of the drug during subsequent milling. The lyophilized drug is milled in fluid energy mills that have been fitted with abrasion-resistant materials and which use pure nitrogen that has been filtered to eliminate particles of greater than 0.1 .mu.m to transport the drug. The use of (a) milling stabilizers in the solution and (b) abrasion-resistant fluid energy mills that use pure filtered nitrogen in the milling step reduce insoluble contaminants and inactive fractions in the milled product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.