Estradiol derivative-chlorambucil conjugate process for preparing the same, and pharmaceutical composition
US5354745A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 3, 1993 |
| Grant date | Oct 11, 1994 |
| Priority date | — |
| Expiry date | Jun 3, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0072
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.