Optically active N-.alpha.-fluoroacryloylamino acid derivatives for the resolution of racemates

US5354884A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rolf Grosser · Schwandorf, DE
• Walter Lange · Cologne, DE
• Bruno Bomer · Bensberg, DE
• Dieter Arlt · Cologne, DE
• Dietmar Bielefeldt · Ratingen, DE

Key dates

• Filing date: Oct 1, 1992
• Grant date: Oct 11, 1994
• Expiry date: Oct 1, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/42
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

.alpha.-Fluoro-substituted N-acryloylamino acid derivatives of the formula ##STR1## are used to make polymers optionally for chromatographic resolution of racemates into their enantiomers. The fluorine atom improves performance in many instances.