Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
US5356887A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 7, 1993 |
| Grant date | Oct 18, 1994 |
| Priority date | — |
| Expiry date | Sep 7, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/66
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Crystalline and amorphous insoluble calcium salts of bisphosphonic acids may be formulated to provide compositions suitable for I.M. (intramuscular) and S.C. (subcutaneous) administration. As compared to solutions of the soluble salts of bisphosphonic acids, suspensions of the crystalline and amorphous calcium salts provide slow systemic release of the bisphosphonic acid and reduce tissue damage and localized pain and irritation when used in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.