Benzanilide derivatives

US5356893A · kind A · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• John Bradshaw · Solon, US
• John W. Clitherow · Sawbridgeworth, GB
• Ian Baxter Campbell

Key dates

• Filing date: Sep 17, 1992
• Grant date: Oct 18, 1994
• Expiry date: Sep 17, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/155
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt or solvate thereof wherein R.sup.1 represents a halogen or hydrogen atom or a C.sub.1-6 alkyl or C.sub.1-6 alkoxy group; PA1 R.sup.2 represents a phenyl group optionally substituted by one or two substituents; PA1 R.sup.3 represents the group ##STR2## R.sup.4 and R.sup.5, which may be the same or different, each independently represent a hydrogen atom or a halogen atom, or a group selected from hydroxy, C.sub.1-6 alkoxy or C.sub.1-6 alkyl. The compounds may be used in the treatment or prophylaxis of depression and other CNS disorders.