Imidazolylphenol compounds, pharmaceutical compositions containing them, and processes for preparing such compounds and compositions

US5356921A · kind A · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Joachim Ammann · Aachen, DE
• Michael Haurand · Aachen, DE
• Cornelia Geist · Aachen, DE
• Werner Englberger · Stolberg, DE
• Oswald Zimmer · Würselen, DE

Key dates

• Filing date: Feb 17, 1993
• Grant date: Oct 18, 1994
• Expiry date: Feb 17, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

3- and 4-(1H-imidazol-1-yl)phenol compounds corresponding to the formula I ##STR1## in which R.sup.1 represents NH.sub.2 or CH.sub.3, R.sup.2 represents H or CH.sub.3, X represents O or S, Y represents H, OH or OCH.sub.3, and Z represents --CH.dbd.CH--, O or S, or their salts, which exhibit 5-lipoxygenase and thromboxane synthase inhibiting activities.