Patent · US Expired

PH-triggered osmotic bursting delivery devices

US5358502A · kind A · utility

14Cited by
18References
14Claims
0Family size

Assignee

Inventors

Key dates

Filing dateFeb 25, 1993
Grant dateOct 25, 1994
Priority date—
Expiry dateFeb 25, 2013

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61P43/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsule halves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable the pH-triggered release of the beneficial agent core as a bolus by osmotic bursting.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.