Genetic detoxification of pertussis toxin
US5358868A · kind A · utility
31Cited by
0References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 5, 1991 |
| Grant date | Oct 25, 1994 |
| Priority date | — |
| Expiry date | Nov 5, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these holotoxin analogues are detoxified, retain an immunodominant S1 epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.