Imidazopyridine PAF/H.sub.1 antagonists
US5358953A · kind A · utility
24Cited by
2References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 12, 1993 |
| Grant date | Oct 25, 1994 |
| Priority date | — |
| Expiry date | Jul 12, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of formula (1), wherein X is CH or N; Z is CH.dbd.CH or S; A is CH.sub.2 CH.sub.2, CH.dbd.CH, CH(OH)CH.sub.2, or COCH.sub.2 ; B is a direct link or --CH.sub.2 --, --CH(CH.sub.3)-- or --C(CH.sub.3).sub.2 --; or when Z is CH.dbd.CH, B may form a cyclopentane ring fused to the attached benzene ring; Y completes a fused benzo or thienyl ring which is optionally substituted by halo or C.sub.1 -C.sub.4 alkyl; n is 0, 1 or 2; and m is 0 or 1; are antagonists of both PAF and histamine H.sub.1 having utility in the treatment of allergic inflammatory conditions such as allergic rhinitis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.