Cysteine depleted IL-6 muteins
US5359034A · kind A · utility
13Cited by
1References
10Claims
0Family size
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Key dates
| Filing date | Jul 2, 1992 |
| Grant date | Oct 25, 1994 |
| Priority date | — |
| Expiry date | Jul 2, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/141
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Muteins of IL-6 and truncated IL-6 are prepared by recombinant DNA techniques. In the muteins, the cysteine residues that occur at positions, or at positions corresponding to positions, 45 and 51 of mature, native IL-6 have been replaced by other amino acids. The cysteine residues that occur at positions, or at positions corresponding to positions, 74 and 84 are retained. The molecule has biological activity that is at least comparable to that of native IL-6.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.