Nucleic acids encoding DNA structure-specific recognition protein and uses therefor

US5359047A · kind A · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Brian Donahue · Menlo Park, US
• Jeffrey H. Toney · Westfield, US
• John M. Essigmann · Cambridge, US
• Stephen J. Lippard · Cambridge, US
• Pieter M. Pil · New Haven, US
• Suzanne Bruhn · Cambridge, US
• Steven Brown · Village of La Jolla, US
• Patti J. Kellett · Cincinnati, US

Key dates

• Filing date: Dec 26, 1991
• Grant date: Oct 25, 1994
• Expiry date: Dec 26, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.