Process for the preparation of a R-alpha cyclopentenones and R-alpha and R-omega cyclopentanoids
US5359110A · kind A · utility
1Cited by
4References
12Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 16, 1993 |
| Grant date | Oct 25, 1994 |
| Priority date | — |
| Expiry date | Nov 16, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of R.alpha.-cyclopentenoids and then R.alpha., R.omega.-cyclopentanoids is described. The process involves the reaction of a compound of the formula ##STR1## where X is halo, particularly Br or I and P is a protecting group with an alkylborane to produce the R.alpha.-cyclopentenone. The R.alpha.-cyclopentenone is reacted with a R.omega. cuprate to produce the R.alpha., R.omega.-cyclopentenoid. The process is used for the preparation of prostaglandins which are known pharmaceutically active compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.