1,3-dioxane derivatives having protein kinase C inhibitory activity
US5360818A · kind A · utility
6Cited by
7References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 24, 1993 |
| Grant date | Nov 1, 1994 |
| Priority date | — |
| Expiry date | Aug 24, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D319/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds having the formula ##STR1## wherein R.sub.1 is alkyl, alkenyl and alkynyl having from 2 to about 20 carbon atoms; R.sub.2, R.sub.3 and R.sub.6 are independently H, phenyl or alkyl having from 1 to about 20 carbon atoms; and R.sub.4 and R.sub.5 are independently H, R.sub.6 imino, or amidino, and pharmaceutically acceptable salts thereof which are useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.