Derivatized gold clusters and antibody-gold cluster conjugates
US5360895A · kind A · utility
73Cited by
3References
6Claims
0Family size
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Key dates
| Filing date | Dec 9, 1992 |
| Grant date | Nov 1, 1994 |
| Priority date | — |
| Expiry date | Dec 9, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/585
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antibody- or antibody fragment-gold cluster conjugates are shown wherein the conjugate size can be as small as 5.0 nm. Methods and reagents are disclosed in which antibodies, Fab' or F(ab').sub.2 fragments thereof are covalently bound to a stable cluster of gold atoms. The gold clusters may contain 6, 8, 9, 11, 13, 55 or 67 gold atoms in their inner core. The clusters may also contain radioactive gold. The antibody-cluster conjugates are useful in electron microscopy applications as well as in clinical applications that include imaging, diagnosis and therapy.
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