19F magnetic resonance imaging agents which include a nitroxide moiety

US5362477A · kind A · utility

Assignee

• MallincKrodt Medical, Inc. · US

Inventors

• Dennis A. Moore · Chesterfield, US
• Max D. Adams · Holden, US
• William P. Cacheris · Florissant, US
• David H. White · Ballwin, US
• Muthunadar P. Periasamy · Creve Coeur, US
• Raghavan Rajagopalan · Maryland Heights, US
• Lynn deLearie · University City, US
• Steven R. Woulfe · Ballwin, US

Key dates

• Filing date: Dec 1, 1992
• Grant date: Nov 8, 1994
• Expiry date: Dec 1, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize .sup.19 F magnetic resonance contrast media having enhanced .sup.19 F relaxivity. Fluorine-containing compounds having enhanced .sup.19 F relaxation properties resulting from direct association with an unpaired spin are disclosed. The fluorine-containing compound is associated with the unpaired spin by covalent attachment of a stable free radical, by complexation of a fluorinated complexing agent with a paramagnetic metal ion, or by salt formation or charge neutralization of a paramagnetic ion.