Boronated compounds

US5362732A · kind A · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• Boron Biologicals, Inc. · US
• Duke University · US

Inventors

• Bernard F. Spielvogel · Cary, US
• Anup Sood · Flemington, US
• Iris H. Hall · Chapel Hill, US
• Barbara Ramsay Shaw · Durham, US
• Jeno Tomasz · Durham, US

Key dates

• Filing date: Jul 7, 1992
• Grant date: Nov 8, 1994
• Expiry date: Jul 7, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H23/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A novel class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated purine and pyrimidine bases and boronated nucleosides, as well as phosphate esters and oligomers thereof. The compounds are boronated at the ring nitrogen of the purine or pyrimidine base, or at a 2', 3' or 5' amino substituent of the nucleoside sugar.