M-EDTA pharmaceutical preparations and uses thereof
US5362754A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 12, 1992 |
| Grant date | Nov 8, 1994 |
| Priority date | — |
| Expiry date | Nov 12, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2025/0056
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Disclosed are pharmaceutical compositions of a mixture of minocycline and EDTA (M-EDTA) and methods of using the compositions in maintaining the patency of a catheter port. Methods for inhibiting the formation of polysaccharide-rich glycocalyx (such as the glycocalyx of staphylococcal organisms) are also provided using an M-EDTA solution. The M-EDTA solution may also be used to pretreat a medical device to prevent adherence of infectious organisms, such as S. epidermidis and S. aureus. The compositions destroy and prevent the formation of polysaccharide-rich glycocalyx. Methods for treating infections of S. epidermidis and S. aureus where glycocalyx formation are provided with an M-EDTA solution. The minocycline and EDTA solutions are included together within a pharmacologically acceptable carrier solution, such as saline.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.